Brekiya Now Available for Migraine, Cluster Headache Treatment

Brekiya Now Available for Migraine and Cluster Headache Treatment

Brekiya, a ready-to-use dihydroergotamine (DHE) autoinjector, is now available for the acute treatment of migraine with or without aura and cluster headaches in adults.

Brekiya is supplied as a 1mL prefilled single-dose autoinjector containing 1mg/mL of DHE, an ergotamine derivative, which works by agonist effects at 5-HT1D receptors in patients with migraine.

As the first and only self-administered, ready-to-use DHE autoinjector, Brekiya offers patients the ability to treat debilitating attacks in a convenient way and avoid visits to the emergency room.

Brekiya does not require refrigeration, assembly, or priming of the device, making it a convenient treatment option.

Author summary: Brekiya is a new treatment for migraines and cluster headaches.

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Clinical Pain Advisor Clinical Pain Advisor — 2025-10-28

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