Intracellular GPCR Targeting Unlocks New Biased Therapies
A new study reveals that targeting G protein-coupled receptors (GPCRs) with biased modulators can expand potential drug targets and reduce side effects.
GPCRs are the largest family of cell membrane receptors and play a crucial role in maintaining human health, as they are involved in nearly every physiological function.
- Approximately one-third of all FDA-approved drugs target GPCRs.
- GPCRs detect a wide variety of biological signaling molecules outside the cell.
- These signals activate proteins called G proteins and beta-arrestins inside the cell.
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Author's summary: New study on GPCR targeting unlocks new therapies.