Hopes of immediately reopening the federal government were dashed as the Senate failed, for the 13th time, to pass a House-backed funding measure.
The vote on the bill to fund the government failed 54-45, falling short of the 60 votes required to move forward.
The partisan deadlock on Capitol Hill continues a bitter battle between Republicans and Democrats, now on its 28th day.
The lack of progress means the shutdown will likely continue, inching the nation one step closer to what could become the longest government shutdown in history.
Author's summary: Government shutdown deepens amid failed Senate vote.